Synthesis of γ-Oxo-α-amino Acids via Radical Acylation with Carboxylic Acids

Herein we present a highly efficient, light-mediated, deoxygenative protocol to access γ-oxo-α-amino acid derivatives. This radical methodology employs photoredox catalysis, in combination with triphenylphosphine, generate acyl radicals from readily available (hetero)aromatic and vinylic carboxylic acids. approach allows for the straightforward synthesis of acids bearing wide range functional groups (e.g., Cl, CN, furan, thiophene, Bpin) synthetically useful yields (∼60% average yield). To further highlight utility methodology, several deprotection derivatization reactions were carried out.